RapamycinFungusV1, Main, Exploration, bibRecord, 000C67

Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Identifieur interne : 000C67 ( Main/Exploration ); précédent : 000C66; suivant : 000C68

Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Auteurs : Shigeaki Saitoh [Japon] ; Ayaka Mori [Japon] ; Lisa Uehara [Japon] ; Fumie Masuda [Japon] ; Saeko Soejima [Japon] ; Mitsuhiro Yanagida [Japon]

Source :

Molecular biology of the cell [ 1939-4586 ] ; 2015.

RBID : pubmed:25411338

Descripteurs français

English descriptors

Abstract

Hexose transporters are required for cellular glucose uptake; thus they play a pivotal role in glucose homeostasis in multicellular organisms. Using fission yeast, we explored hexose transporter regulation in response to extracellular glucose concentrations. The high-affinity transporter Ght5 is regulated with regard to transcription and localization, much like the human GLUT transporters, which are implicated in diabetes. When restricted to a glucose concentration equivalent to that of human blood, the fission yeast transcriptional regulator Scr1, which represses Ght5 transcription in the presence of high glucose, is displaced from the nucleus. Its displacement is dependent on Ca(2+)/calmodulin-dependent kinase kinase, Ssp1, and Sds23 inhibition of PP2A/PP6-like protein phosphatases. Newly synthesized Ght5 locates preferentially at the cell tips with the aid of the target of rapamycin (TOR) complex 2 signaling. These results clarify the evolutionarily conserved molecular mechanisms underlying glucose homeostasis, which are essential for preventing hyperglycemia in humans.

DOI: 10.1091/mbc.E14-11-1503
PubMed: 25411338
PubMed Central: PMC4294683

Affiliations:

Japon

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Le document en format XML

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<author><name sortKey="Masuda, Fumie" sort="Masuda, Fumie" uniqKey="Masuda F" first="Fumie" last="Masuda">Fumie Masuda</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active Transport, Cell Nucleus (drug effects)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Kinase (genetics)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Kinase (metabolism)</term>
<term>Cell Cycle Proteins (genetics)</term>
<term>Cell Cycle Proteins (metabolism)</term>
<term>Cell Nucleus (metabolism)</term>
<term>Gene Expression Regulation, Fungal (drug effects)</term>
<term>Glucose (metabolism)</term>
<term>Glucose (pharmacokinetics)</term>
<term>Glucose (pharmacology)</term>
<term>Glucose Transport Proteins, Facilitative (genetics)</term>
<term>Glucose Transport Proteins, Facilitative (metabolism)</term>
<term>Green Fluorescent Proteins (genetics)</term>
<term>Green Fluorescent Proteins (metabolism)</term>
<term>HSP70 Heat-Shock Proteins (genetics)</term>
<term>HSP70 Heat-Shock Proteins (metabolism)</term>
<term>Humans (MeSH)</term>
<term>Immunoblotting (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (MeSH)</term>
<term>Microscopy, Fluorescence (MeSH)</term>
<term>Monosaccharide Transport Proteins (genetics)</term>
<term>Monosaccharide Transport Proteins (metabolism)</term>
<term>Multiprotein Complexes (genetics)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Mutation (MeSH)</term>
<term>Phosphoprotein Phosphatases (genetics)</term>
<term>Phosphoprotein Phosphatases (metabolism)</term>
<term>Protein Isoforms (genetics)</term>
<term>Protein Isoforms (metabolism)</term>
<term>Schizosaccharomyces (genetics)</term>
<term>Schizosaccharomyces (metabolism)</term>
<term>Schizosaccharomyces pombe Proteins (genetics)</term>
<term>Schizosaccharomyces pombe Proteins (metabolism)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Time-Lapse Imaging (methods)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Calcium-Calmodulin-Dependent Protein Kinase Kinase (génétique)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Kinase (métabolisme)</term>
<term>Complexe-2 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (génétique)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Glucose (métabolisme)</term>
<term>Glucose (pharmacocinétique)</term>
<term>Glucose (pharmacologie)</term>
<term>Humains (MeSH)</term>
<term>Imagerie accélérée (méthodes)</term>
<term>Immunotransfert (MeSH)</term>
<term>Isoformes de protéines (génétique)</term>
<term>Isoformes de protéines (métabolisme)</term>
<term>Microscopie de fluorescence (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Noyau de la cellule (métabolisme)</term>
<term>Phosphoprotein Phosphatases (génétique)</term>
<term>Phosphoprotein Phosphatases (métabolisme)</term>
<term>Protéines de Schizosaccharomyces pombe (génétique)</term>
<term>Protéines de Schizosaccharomyces pombe (métabolisme)</term>
<term>Protéines du choc thermique HSP70 (génétique)</term>
<term>Protéines du choc thermique HSP70 (métabolisme)</term>
<term>Protéines du cycle cellulaire (génétique)</term>
<term>Protéines du cycle cellulaire (métabolisme)</term>
<term>Protéines à fluorescence verte (génétique)</term>
<term>Protéines à fluorescence verte (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (effets des médicaments et des substances chimiques)</term>
<term>Schizosaccharomyces (génétique)</term>
<term>Schizosaccharomyces (métabolisme)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transport nucléaire actif (effets des médicaments et des substances chimiques)</term>
<term>Transporteurs de glucose par diffusion facilitée (génétique)</term>
<term>Transporteurs de glucose par diffusion facilitée (métabolisme)</term>
<term>Transporteurs de monosaccharides (génétique)</term>
<term>Transporteurs de monosaccharides (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium-Calmodulin-Dependent Protein Kinase Kinase</term>
<term>Cell Cycle Proteins</term>
<term>Glucose Transport Proteins, Facilitative</term>
<term>Green Fluorescent Proteins</term>
<term>HSP70 Heat-Shock Proteins</term>
<term>Monosaccharide Transport Proteins</term>
<term>Multiprotein Complexes</term>
<term>Phosphoprotein Phosphatases</term>
<term>Protein Isoforms</term>
<term>Schizosaccharomyces pombe Proteins</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Active Transport, Cell Nucleus</term>
<term>Gene Expression Regulation, Fungal</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Régulation de l'expression des gènes fongiques</term>
<term>Transport nucléaire actif</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Calcium-Calmodulin-Dependent Protein Kinase Kinase</term>
<term>Complexes multiprotéiques</term>
<term>Isoformes de protéines</term>
<term>Phosphoprotein Phosphatases</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Protéines du choc thermique HSP70</term>
<term>Protéines du cycle cellulaire</term>
<term>Protéines à fluorescence verte</term>
<term>Schizosaccharomyces</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transporteurs de glucose par diffusion facilitée</term>
<term>Transporteurs de monosaccharides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium-Calmodulin-Dependent Protein Kinase Kinase</term>
<term>Cell Cycle Proteins</term>
<term>Cell Nucleus</term>
<term>Glucose</term>
<term>Glucose Transport Proteins, Facilitative</term>
<term>Green Fluorescent Proteins</term>
<term>HSP70 Heat-Shock Proteins</term>
<term>Monosaccharide Transport Proteins</term>
<term>Multiprotein Complexes</term>
<term>Phosphoprotein Phosphatases</term>
<term>Protein Isoforms</term>
<term>Schizosaccharomyces</term>
<term>Schizosaccharomyces pombe Proteins</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Time-Lapse Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcium-Calmodulin-Dependent Protein Kinase Kinase</term>
<term>Complexes multiprotéiques</term>
<term>Glucose</term>
<term>Isoformes de protéines</term>
<term>Noyau de la cellule</term>
<term>Phosphoprotein Phosphatases</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Protéines du choc thermique HSP70</term>
<term>Protéines du cycle cellulaire</term>
<term>Protéines à fluorescence verte</term>
<term>Schizosaccharomyces</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transporteurs de glucose par diffusion facilitée</term>
<term>Transporteurs de monosaccharides</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Imagerie accélérée</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Glucose</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Glucose</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Glucose</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Glucose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Immunoblotting</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Microscopy, Fluorescence</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Humains</term>
<term>Immunotransfert</term>
<term>Microscopie de fluorescence</term>
<term>Mutation</term>
</keywords>
</textClass>
</profileDesc>
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<front><div type="abstract" xml:lang="en">Hexose transporters are required for cellular glucose uptake; thus they play a pivotal role in glucose homeostasis in multicellular organisms. Using fission yeast, we explored hexose transporter regulation in response to extracellular glucose concentrations. The high-affinity transporter Ght5 is regulated with regard to transcription and localization, much like the human GLUT transporters, which are implicated in diabetes. When restricted to a glucose concentration equivalent to that of human blood, the fission yeast transcriptional regulator Scr1, which represses Ght5 transcription in the presence of high glucose, is displaced from the nucleus. Its displacement is dependent on Ca(2+)/calmodulin-dependent kinase kinase, Ssp1, and Sds23 inhibition of PP2A/PP6-like protein phosphatases. Newly synthesized Ght5 locates preferentially at the cell tips with the aid of the target of rapamycin (TOR) complex 2 signaling. These results clarify the evolutionarily conserved molecular mechanisms underlying glucose homeostasis, which are essential for preventing hyperglycemia in humans. </div>
</front>
</TEI>
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<DateCompleted><Year>2015</Year>
<Month>10</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1939-4586</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>26</Volume>
<Issue>2</Issue>
<PubDate><Year>2015</Year>
<Month>Jan</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Molecular biology of the cell</Title>
<ISOAbbreviation>Mol Biol Cell</ISOAbbreviation>
</Journal>
<ArticleTitle>Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.</ArticleTitle>
<Pagination><MedlinePgn>373-86</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1091/mbc.E14-11-1503</ELocationID>
<Abstract><AbstractText>Hexose transporters are required for cellular glucose uptake; thus they play a pivotal role in glucose homeostasis in multicellular organisms. Using fission yeast, we explored hexose transporter regulation in response to extracellular glucose concentrations. The high-affinity transporter Ght5 is regulated with regard to transcription and localization, much like the human GLUT transporters, which are implicated in diabetes. When restricted to a glucose concentration equivalent to that of human blood, the fission yeast transcriptional regulator Scr1, which represses Ght5 transcription in the presence of high glucose, is displaced from the nucleus. Its displacement is dependent on Ca(2+)/calmodulin-dependent kinase kinase, Ssp1, and Sds23 inhibition of PP2A/PP6-like protein phosphatases. Newly synthesized Ght5 locates preferentially at the cell tips with the aid of the target of rapamycin (TOR) complex 2 signaling. These results clarify the evolutionarily conserved molecular mechanisms underlying glucose homeostasis, which are essential for preventing hyperglycemia in humans. </AbstractText>
<CopyrightInformation>© 2015 Saitoh et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Saitoh</LastName>
<ForeName>Shigeaki</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Life Science, Kurume University, Hyakunen-Kohen 1-1, Kurume, Fukuoka 839-0864, Japan saitou_shigeaki@kurume-u.ac.jp myanagid@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mori</LastName>
<ForeName>Ayaka</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Okinawa Institute Science and Technology Graduate University, Tancha 1919-1, Onna, Okinawa 904-0495, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uehara</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Okinawa Institute Science and Technology Graduate University, Tancha 1919-1, Onna, Okinawa 904-0495, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Masuda</LastName>
<ForeName>Fumie</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Institute of Life Science, Kurume University, Hyakunen-Kohen 1-1, Kurume, Fukuoka 839-0864, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Soejima</LastName>
<ForeName>Saeko</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Life Science, Kurume University, Hyakunen-Kohen 1-1, Kurume, Fukuoka 839-0864, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yanagida</LastName>
<ForeName>Mitsuhiro</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Okinawa Institute Science and Technology Graduate University, Tancha 1919-1, Onna, Okinawa 904-0495, Japan saitou_shigeaki@kurume-u.ac.jp myanagid@gmail.com.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>11</Month>
<Day>19</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>United States</Country>
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	Serveur d'exploration sur la rapamycine et les champignons
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Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

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